Title |
The ‘Checkmate’ for Iron Between Human Host and Invading Bacteria: Chess Game Analogy
|
---|---|
Published in |
Indian Journal of Microbiology, May 2018
|
DOI | 10.1007/s12088-018-0740-2 |
Pubmed ID | |
Authors |
V. Kalidasan, Narcisse Joseph, Suresh Kumar, Rukman Awang Hamat, Vasantha Kumari Neela |
Abstract |
Iron is an essential nutrient for all living organisms with critical roles in many biological processes. The mammalian host maintains the iron requirements by dietary intake, while the invading pathogenic bacteria compete with the host to obtain those absorbed irons. In order to limit the iron uptake by the bacteria, the human host employs numerous iron binding proteins and withholding defense mechanisms that capture iron from the microbial invaders. To counteract, the bacteria cope with the iron limitation imposed by the host by expressing various iron acquisition systems, allowing them to achieve effective iron homeostasis. The armamentarium used by the human host and invading bacteria, leads to the dilemma of who wins the ultimate war for iron. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 17% |
Student > Ph. D. Student | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Lecturer | 2 | 6% |
Student > Bachelor | 1 | 3% |
Other | 4 | 11% |
Unknown | 17 | 49% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Medicine and Dentistry | 3 | 9% |
Immunology and Microbiology | 3 | 9% |
Agricultural and Biological Sciences | 2 | 6% |
Environmental Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 19 | 54% |