Title |
Opioidergic Modulation of Striatal Circuits, Implications in Parkinson's Disease and Levodopa Induced Dyskinesia
|
---|---|
Published in |
Frontiers in Neurology, July 2018
|
DOI | 10.3389/fneur.2018.00524 |
Pubmed ID | |
Authors |
Stefania Sgroi, Raffaella Tonini |
Abstract |
The functional organization of the dorsal striatum is complex, due to the diversity of neural inputs that converge in this structure and its subdivision into direct and indirect output pathways, striosomes and matrix compartments. Among the neurotransmitters that regulate the activity of striatal projection neurons (SPNs), opioid neuropeptides (enkephalin and dynorphin) play a neuromodulatory role in synaptic transmission and plasticity and affect striatal-based behaviors in both normal brain function and pathological states, including Parkinson's disease (PD). We review recent findings on the cell-type-specific effects of opioidergic neurotransmission in the dorsal striatum, focusing on the maladaptive synaptic neuroadaptations that occur in PD and levodopa-induced dyskinesia. Understanding the plethora of molecular and synaptic mechanisms underpinning the opioid-mediated modulation of striatal circuits is critical for the development of pharmacological treatments that can alleviate motor dysfunctions and hyperkinetic responses to dopaminergic stimulant drugs. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 29% |
Student > Bachelor | 12 | 18% |
Researcher | 9 | 13% |
Student > Master | 5 | 7% |
Student > Doctoral Student | 4 | 6% |
Other | 8 | 12% |
Unknown | 10 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 23 | 34% |
Agricultural and Biological Sciences | 12 | 18% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Medicine and Dentistry | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 6 | 9% |
Unknown | 11 | 16% |