Title |
Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly
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Published in |
Annals of Nutrition and Metabolism, June 2018
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DOI | 10.1159/000490003 |
Pubmed ID | |
Authors |
Romana Novaković, Anouk Geelen, Danijela Ristić-Medić, Marina Nikolić, Olga W. Souverein, Helene McNulty, Maresa Duffy, Leane Hoey, Carla Dullemeijer, Jacoba M.S. Renkema, Mirjana Gurinović, Marija Glibetić, Lisette C.P.G.M. de Groot, Pieter van’t Veer |
Abstract |
Dietary reference values for folate intake vary widely across Europe. MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and -16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21-0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21-0.36) for RBC (13 estimates from 11 studies), and β = -0.21 (95% CI -0.31 to -0.11) for plasma homocysteine (10 estimates from 6 studies). These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 14% |
India | 1 | 14% |
United Kingdom | 1 | 14% |
Austria | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 20% |
Student > Ph. D. Student | 5 | 14% |
Student > Master | 5 | 14% |
Lecturer | 4 | 11% |
Other | 1 | 3% |
Other | 4 | 11% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Nursing and Health Professions | 7 | 20% |
Medicine and Dentistry | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Agricultural and Biological Sciences | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 4 | 11% |
Unknown | 12 | 34% |