Title |
Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers
|
---|---|
Published in |
Frontiers in Pharmacology, June 2018
|
DOI | 10.3389/fphar.2018.00683 |
Pubmed ID | |
Authors |
Lisa M. Fleischer, Rachana D. Somaiya, Gregory M. Miller |
Abstract |
Since its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell activation has become a topic of emerging interest. Here, we review the immunologically-relevant TAAR1 literature and incorporate open-source expression and cancer survival data meta-analyses. We provide strong evidence for TAAR1 expression in the immune system and cancers revealed through NCBI GEO datamining and discuss its regulation in a spectrum of immune cell types as well as in numerous cancers. We discuss connections and logical directions for further study of TAAR1 in immunological function, and its potential role as a mediator or modulator of immune dysregulation, immunological effects of psychostimulant drugs of abuse, and cancer progression. |
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Geographical breakdown
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 66 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 14% |
Student > Master | 9 | 14% |
Student > Ph. D. Student | 7 | 11% |
Student > Bachelor | 6 | 9% |
Student > Doctoral Student | 4 | 6% |
Other | 12 | 18% |
Unknown | 19 | 29% |
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Pharmacology, Toxicology and Pharmaceutical Science | 8 | 12% |
Neuroscience | 7 | 11% |
Agricultural and Biological Sciences | 5 | 8% |
Medicine and Dentistry | 5 | 8% |
Other | 11 | 17% |
Unknown | 22 | 33% |