Title |
Transcriptional Enhancers in the Regulation of T Cell Differentiation
|
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Published in |
Frontiers in immunology, September 2015
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DOI | 10.3389/fimmu.2015.00462 |
Pubmed ID | |
Authors |
Michelle L. T. Nguyen, Sarah A. Jones, Julia E. Prier, Brendan E. Russ |
Abstract |
The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are choreographed by the interplay between transcription factors and epigenetic regulators that act to restructure the genome, ultimately ensuring lineage-appropriate gene expression. Here, we focus on the mechanisms that control T cell differentiation, with a particular focus on the role of regulatory elements encoded within the genome, known as transcriptional enhancers (TEs). We discuss the central role of TEs in regulating T cell differentiation, both in health and disease. |
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Switzerland | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Germany | 2 | 2% |
Luxembourg | 1 | <1% |
Unknown | 98 | 97% |
Demographic breakdown
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Student > Ph. D. Student | 21 | 21% |
Student > Bachelor | 18 | 18% |
Researcher | 17 | 17% |
Student > Master | 13 | 13% |
Student > Doctoral Student | 10 | 10% |
Other | 10 | 10% |
Unknown | 12 | 12% |
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Immunology and Microbiology | 12 | 12% |
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Nursing and Health Professions | 3 | 3% |
Other | 11 | 11% |
Unknown | 12 | 12% |