Title |
The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
|
---|---|
Published in |
Frontiers in Neuroscience, August 2018
|
DOI | 10.3389/fnins.2018.00520 |
Pubmed ID | |
Authors |
Lucrezia Cellai, Kevin Carvalho, Emilie Faivre, Aude Deleau, Didier Vieau, Luc Buée, David Blum, Céline Mériaux, Victoria Gomez-Murcia |
Abstract |
Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 18% |
Canada | 1 | 9% |
Italy | 1 | 9% |
Spain | 1 | 9% |
Belgium | 1 | 9% |
Switzerland | 1 | 9% |
Unknown | 4 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 82% |
Scientists | 2 | 18% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 66 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 14% |
Student > Bachelor | 9 | 14% |
Researcher | 8 | 12% |
Student > Ph. D. Student | 8 | 12% |
Other | 6 | 9% |
Other | 9 | 14% |
Unknown | 17 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 17% |
Neuroscience | 10 | 15% |
Medicine and Dentistry | 7 | 11% |
Agricultural and Biological Sciences | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Other | 7 | 11% |
Unknown | 20 | 30% |