Title |
How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets
|
---|---|
Published in |
Frontiers in immunology, June 2018
|
DOI | 10.3389/fimmu.2018.01450 |
Pubmed ID | |
Authors |
Haiguang Wang, Kristin A. Hogquist |
Abstract |
In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules. There are three major functionally distinct effector states for iNKT cells. Owning to these innate-like effector states, iNKT cells have been implicated in early protective immunity against pathogens. Yet, growing evidence suggests that iNKT cells play a role in tissue homeostasis as well. In this review, we discuss current knowledge about the underlying mechanisms that regulate the effector states of iNKT subsets, with a highlight on the roles of a variety of transcription factors and describe how each subset influences different facets of thymus homeostasis. |
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