Title |
Dual-Responsive Core Crosslinking Glycopolymer-Drug Conjugates Nanoparticles for Precise Hepatocarcinoma Therapy
|
---|---|
Published in |
Frontiers in Pharmacology, July 2018
|
DOI | 10.3389/fphar.2018.00663 |
Pubmed ID | |
Authors |
Jing Wu, Jiayi Yuan, Baotong Ye, Yaling Wu, Zheng Xu, Jinghua Chen, Jingxiao Chen |
Abstract |
Nanoparticles (NPs) have demonstrated a potential for hepatocarcinoma therapy. However, the effective and safe NP-mediated drug transportation is still challenging due to premature leakage and inaccurate release of the drug. Herein, we designed a series of core cross-linking galactose-based glycopolymer-drug conjugates (GPDs) NPs with both redox-responsive and pH-sensitive characteristics to target and program drug release. Glycopolymer is comprised of galactose-containing units, which gather on the surface of GPD NPs and exhibit specific recognition to hepatocarcinoma cells, which over-express the asialoglycoprotein receptor. GPD NPs are stable in a normal physiological environment and can rapidly release the drug in hepatocarcinoma cells, which are reductive and acidic, by combining disulfide bond cross-linked core, as well as boronate ester-linked hydrophilic glycopolymer chain and the hydrophobic drug. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 18% |
Student > Ph. D. Student | 5 | 15% |
Student > Doctoral Student | 3 | 9% |
Researcher | 3 | 9% |
Other | 3 | 9% |
Other | 6 | 18% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 12 | 36% |
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Chemical Engineering | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Materials Science | 2 | 6% |
Other | 1 | 3% |
Unknown | 9 | 27% |