Title |
COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents
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Published in |
Frontiers in Genetics, July 2018
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DOI | 10.3389/fgene.2018.00284 |
Pubmed ID | |
Authors |
Sabina K. Millenet, Frauke Nees, Stefan Heintz, Christiane Bach, Josef Frank, Sabine Vollstädt-Klein, Arun Bokde, Uli Bromberg, Christian Büchel, Erin B. Quinlan, Sylvane Desrivières, Juliane Fröhner, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Herve Lemaire, Jean-Luc Martinot, Marie-Laure P. Martinot, Dimitri O. Papadoulos, Tomáš Paus, Luise Poustka, Marcella Rietschel, Michael N. Smolka, Henrik Walter, Rob Whelan, Gunter Schumann, Tobias Banaschewski, Sarah Hohmann |
Abstract |
The dopaminergic system has been shown to have substantial effects on the etiology of attention-deficit hyperactivity disorder (ADHD). However, while some studies found a significant direct effect, others did not. In this context, social behavior might play an important role as a factor that is related both to the dopaminergic system and ADHD. In a large epidemiological sample of adolescents (N = 462; 16-17 years), we assessed the level of ADHD symptoms using the Strengths and Difficulties Questionnaire, social behavior using the Social Responsiveness Scale, and the allelic distribution of the dopaminergic catechol-O-methyltransferase (COMT) Val158Met polymorphism. We found a significant association between COMT and social impairment, insofar as Met-allele carriers showed increased levels of social impairment. Moreover, social impairment significantly determined an association between COMT and ADHD (explained variance: 19.09%). This effect did not significantly differ between males and females. COMT and social impairment might interactively affect ADHD symptomatology, and could thus represent significant gene-phenotypic risk factors for ADHD symptomatology. This might have interesting implications for prevention and intervention strategies with a focus on social behavior in genetically at-risk individuals. |
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