Title |
Wnt/β-Catenin Signaling and Obesity
|
---|---|
Published in |
Frontiers in Physiology, July 2018
|
DOI | 10.3389/fphys.2018.00792 |
Pubmed ID | |
Authors |
Na Chen, Jiqiu Wang |
Abstract |
Obesity has become epidemic worldwide, which triggers several obesity-associated complications. Obesity is characterized by excess fat storage mainly in the visceral white adipose tissue (vWAT), subcutaneous WAT (sWAT), and other tissues. Myriad studies have demonstrated the crucial role of canonical Wnt/β-catenin cascade in the development of organs and physiological homeostasis, whereas recent studies show that genetic variations/mutations in the Wnt/β-catenin pathway are associated with human metabolic diseases. In this review, we highlight the regulation of updated Wnt/β-catenin signaling in obesity, especially the distinctly depot-specific roles between subcutaneous and visceral adipose tissue under high-fed diet stimulation and WAT browning process. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 110 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 21% |
Student > Bachelor | 13 | 12% |
Researcher | 12 | 11% |
Student > Master | 12 | 11% |
Student > Doctoral Student | 11 | 10% |
Other | 13 | 12% |
Unknown | 26 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 38 | 35% |
Medicine and Dentistry | 14 | 13% |
Agricultural and Biological Sciences | 11 | 10% |
Immunology and Microbiology | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 7 | 6% |
Unknown | 32 | 29% |