Title |
Altered Basal Ganglia Network Integration in Schizophrenia
|
---|---|
Published in |
Frontiers in Human Neuroscience, October 2015
|
DOI | 10.3389/fnhum.2015.00561 |
Pubmed ID | |
Authors |
Mingjun Duan, Xi Chen, Hui He, Yuchao Jiang, Sisi Jiang, Qiankun Xie, Yongxiu Lai, Cheng Luo, Dezhong Yao |
Abstract |
The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878. |
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Geographical breakdown
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