Title |
Predominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity
|
---|---|
Published in |
Frontiers in immunology, October 2015
|
DOI | 10.3389/fimmu.2015.00526 |
Pubmed ID | |
Authors |
Xinfang Huang, Stephanie Dorta-Estremera, Yihong Yao, Nan Shen, Wei Cao |
Abstract |
Plasmacytoid dendritic cells (pDCs), which are prominent type I interferon (IFN-I)-producing immune cells, have been extensively implicated in systemic lupus erythematosus (SLE). However, whether they participate critically in lupus pathogenesis remains unknown. Recent studies using various genetic and cell type-specific ablation strategies have demonstrated that pDCs play a pivotal role in the development of autoantibodies and the progression of lupus under diverse experimental conditions. The findings of several investigations highlight a notion that pDCs operate critically at the early stage of lupus development. In particular, pDCs have a profound effect on B-cell activation and humoral autoimmunity in vivo. This deeper understanding of the vital role of pDCs in lupus pathogenesis supports the therapeutic targeting of the pDC-IFN-I pathway in SLE. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 22% |
Researcher | 10 | 17% |
Student > Bachelor | 9 | 16% |
Student > Doctoral Student | 4 | 7% |
Other | 4 | 7% |
Other | 9 | 16% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 15 | 26% |
Medicine and Dentistry | 10 | 17% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Agricultural and Biological Sciences | 7 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 5 | 9% |
Unknown | 9 | 16% |