Title |
T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways
|
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Published in |
Frontiers in oncology, August 2018
|
DOI | 10.3389/fonc.2018.00317 |
Pubmed ID | |
Authors |
Francesco Paduano, Eugenio Gaudio, Afua A. Mensah, Sandra Pinton, Francesco Bertoni, Francesco Trapasso |
Abstract |
Almost 30 years ago, Carlo Croce's group discovered the T-Cell Leukemia/Lymphoma 1A oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in fetal tissues and early developmental stage lymphocytes. Its expression is deregulated in chronic lymphocytic leukemia (B-CLL) and most lymphomas. TCL1 plays a central role in lymphomagenesis as a co-activator of AKT kinases and other recently elucidated interacting protein partners. These include ATM, HSP70 and TP63, which were all confirmed as binding partners of TCL1 from co-immunoprecipitation experiments utilizing endogenously expressed proteins. The nature of these interactions highlighted the role of TCL1 in enhancing multiple signaling pathways, including PI3K and NF-κB. Based on its role in the aforementioned pathways and, despite the lack of a well-defined enzymatic activity, TCL1 is considered a potential therapeutic target for TCL1-positive hematological malignancies. This perspective will provide an overview of TCL1A and its interacting partners. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 20% |
Student > Bachelor | 6 | 17% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
Researcher | 3 | 9% |
Other | 4 | 11% |
Unknown | 9 | 26% |
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Medicine and Dentistry | 5 | 14% |
Agricultural and Biological Sciences | 3 | 9% |
Immunology and Microbiology | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 1 | 3% |
Unknown | 11 | 31% |