Title |
Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage
|
---|---|
Published in |
Frontiers in Neurology, August 2018
|
DOI | 10.3389/fneur.2018.00682 |
Pubmed ID | |
Authors |
Qian-Qian Li, Lan-Jun Li, Xin-Yu Wang, Yu-Ying Sun, Jun Wu |
Abstract |
Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage. Heme oxygenase is the initial and rate-limiting enzyme of heme catabolism, and the expression of heme oxygenase-1 (HO-1) is rapidly induced following acute brain injury. As HO-1 exerts it effects via various metabolites, its role during ICH remains complex. Therefore, in-depth studies regarding the role of HO-1 in secondary brain damage following ICH may provide a theoretical basis for neuroprotective function after ICH. The present review aims to summarize recent key studies regarding the effects of HO-1 following ICH, as well as its influence on ICH prognosis. |
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Mendeley readers
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Student > Master | 2 | 12% |
Unspecified | 1 | 6% |
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Other | 0 | 0% |
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