Title |
Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease
|
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Published in |
Frontiers in Neuroscience, November 2015
|
DOI | 10.3389/fnins.2015.00433 |
Pubmed ID | |
Authors |
Ting Wang, Jesse C. Hay |
Abstract |
Alpha-synuclein is a predominant player in the pathogenesis of Parkinson's Disease. However, despite extensive study for two decades, its physiological and pathological mechanisms remain poorly understood. Alpha-synuclein forms a perplexing web of interactions with lipids, trafficking machinery, and other regulatory factors. One emerging consensus is that synaptic vesicles are likely the functional site for alpha-synuclein, where it appears to facilitate vesicle docking and fusion. On the other hand, the dysfunctions of alpha-synuclein are more dispersed and numerous; when mutated or over-expressed, alpha-synuclein affects several membrane trafficking and stress pathways, including exocytosis, ER-to-Golgi transport, ER stress, Golgi homeostasis, endocytosis, autophagy, oxidative stress, and others. Here we examine recent developments in alpha-synuclein's toxicity in the early secretory pathway placed in the context of emerging themes from other affected pathways to help illuminate its underlying pathogenic mechanisms in neurodegeneration. |
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Country | Count | As % |
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United Kingdom | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
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Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Switzerland | 1 | <1% |
Unknown | 146 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 25 | 17% |
Researcher | 22 | 15% |
Student > Bachelor | 18 | 12% |
Student > Doctoral Student | 9 | 6% |
Other | 23 | 16% |
Unknown | 24 | 16% |
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Biochemistry, Genetics and Molecular Biology | 28 | 19% |
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Immunology and Microbiology | 5 | 3% |
Other | 14 | 9% |
Unknown | 28 | 19% |