Title |
The Ins and Outs of B Cells in Multiple Sclerosis
|
---|---|
Published in |
Frontiers in immunology, November 2015
|
DOI | 10.3389/fimmu.2015.00565 |
Pubmed ID | |
Authors |
Kevin Blauth, Gregory P. Owens, Jeffrey L. Bennett |
Abstract |
B cells play a central role in multiple sclerosis (MS) pathology. B and plasma cells may contribute to disease activity through multiple mechanisms: antigen presentation, cytokine secretion, or antibody production. Molecular analyses of B cell populations in MS patients have revealed significant overlaps between peripheral lymphoid and clonally expanded central nervous system (CNS) B cell populations, indicating that B cell trafficking may play a critical role in driving MS exacerbations. In this review, we will assess our current knowledge of the mechanisms and pathways governing B cell migration into the CNS and examine evidence for and against a compartmentalized B cell response driving progressive MS pathology. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 130 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 27 | 21% |
Student > Ph. D. Student | 21 | 16% |
Student > Bachelor | 15 | 12% |
Student > Master | 15 | 12% |
Other | 13 | 10% |
Other | 21 | 16% |
Unknown | 18 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 22% |
Neuroscience | 21 | 16% |
Agricultural and Biological Sciences | 17 | 13% |
Immunology and Microbiology | 17 | 13% |
Biochemistry, Genetics and Molecular Biology | 13 | 10% |
Other | 7 | 5% |
Unknown | 26 | 20% |