Title |
Aberrations of DNA Repair Pathways in Prostate Cancer: Future Implications for Clinical Practice?
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, September 2018
|
DOI | 10.3389/fcell.2018.00071 |
Pubmed ID | |
Authors |
Orazio Caffo, Antonello Veccia, Stefania Kinspergher, Mimma Rizzo, Francesca Maines |
Abstract |
Patients who are carriers of inherited mutations in essential component of DNA repair pathways have a significantly higher lifetime risk for developing cancer compared to the population of reference. Recent advances in DNA next-generation sequencing technology have allowed screening for carriers of those mutations, allowing development of promising risk-reduction strategies and providing the rationale to personalize the therapeutic approach for these patients. New intriguing scenarios are opening nowadays for the management of prostate cancer in patients with germline or somatic mutations in components of DNA repair pathways (e.g., BRCA1 and BRCA2 genes), such as specific screening policies and new therapeutic strategies involving PARP inhibitors or platinum-based chemotherapy. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 13% |
Unspecified | 3 | 10% |
Researcher | 3 | 10% |
Other | 2 | 6% |
Student > Ph. D. Student | 2 | 6% |
Other | 1 | 3% |
Unknown | 16 | 52% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Unspecified | 3 | 10% |
Agricultural and Biological Sciences | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 14 | 45% |