Claudio Bucolo, Maria Musumeci, Salvatore Salomone, Giovanni Luca Romano, Gian Marco Leggio, Caterina Gagliano, Michele Reibaldi, Teresio Avitabile, Maurizio G. Uva, Salvatore Musumeci, Filippo Drago
Abstract
Purpose: Colostrum has been proposed to treat severe dryness and problematic eye lesions showing a beneficial effect. The aim of the study was to investigate the effect of 2-fucosyl-lactose, a natural sugar present in the human colostrum, in an experimental dry eye. Methods: Dry eye was induced in adult male New Zealand albino rabbits by topical administration of 1% atropine. Tear volume (Schirmer's test), tear film breakup time (TBUT), corneal staining and tear osmolarity were assessed. Fucosyl-lactose eye drops was instilled at different concentrations (0.01, 0.1, and, 1%). Results: After 24 h from first atropine administration, tear volume and TBUT values were significantly improved in groups treated with 2-fucosyl-lactose in a dose-dependent manner. Tear volume increased from 5.25 to 10.75 mm and TBUT values from 8.75 to 34.5 s with 0.01% or 1% 2-fucosyl-lactose treatment, respectively. No changes were observed in terms of corneal staining among the all groups treated with 2-fucosyl-lactose. Atropine instillation caused an increase of tear osmolarity (428 mOsm/L), which was reversed by topical treatment with 2-fucosyl-lactose at all doses. Conclusion: The present study demonstrated that 2-fucosyl-lactose, a human milk oligosaccharide, has protective effect on tear film stability.
Pharmacology, Toxicology and Pharmaceutical Science
4
15%
Biochemistry, Genetics and Molecular Biology
3
12%
Chemistry
1
4%
Other
1
4%
Unknown
7
27%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2015.
All research outputs
#20,296,405
of 22,833,393 outputs
Outputs from Frontiers in Pharmacology
#10,067
of 16,070 outputs
Outputs of similar age
#323,630
of 386,425 outputs
Outputs of similar age from Frontiers in Pharmacology
#60
of 77 outputs
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