Title |
Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus
|
---|---|
Published in |
Frontiers in Pharmacology, August 2018
|
DOI | 10.3389/fphar.2018.00893 |
Pubmed ID | |
Authors |
Aminu Mohammed, Shahidul Islam |
Abstract |
Spices possess tremendous therapeutic potential including hypoglycemic action, attributed to their bioactive ingredients. However, there is no study that critically reviewed the hypoglycemic potency, safety and the bioavailability of the spice-derived bioactive ingredients (SDBI). Therefore, the aim of the study was to comprehensively review all published studies regarding the hypoglycemic action of SDBI with the purpose to assess whether the ingredients are potential hypoglycemic agents or adjuvant. Factors considered were concentration/dosages used, the extent of blood glucose reduction, the IC50 values, and the safety concern of the SDBI. From the results, cinnamaldehyde, curcumin, diosgenin, thymoquinone (TQ), and trigonelline were showed the most promising effects and hold future potential as hypoglycemic agents. Conclusively, future studies should focus on improving the tissue and cellular bioavailability of the promising SDBI to achieve greater potency. Additionally, clinical trials and toxicity studies are with these SDBI are warranted. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 77 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Lecturer | 9 | 12% |
Student > Ph. D. Student | 7 | 9% |
Researcher | 6 | 8% |
Student > Master | 6 | 8% |
Student > Bachelor | 5 | 6% |
Other | 15 | 19% |
Unknown | 29 | 38% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
Medicine and Dentistry | 7 | 9% |
Agricultural and Biological Sciences | 7 | 9% |
Nursing and Health Professions | 4 | 5% |
Other | 9 | 12% |
Unknown | 33 | 43% |