Polygenicity of complex traits is explained by negative selection

All of the 'flattening the curve' talks remind me of this paper by @Luke0connor "Polygenicity of complex traits is explained by negative selection." https://t.co/IIjMBy4wVs here 'flattening' = negative selection constraining the maximum effect size

RT @mrtnj: Li: Why don't common variants close to for genes have large effect sizes? Probably natural selection. C.f. "flattening" https://…

RT @mrtnj: Li: Why don't common variants close to for genes have large effect sizes? Probably natural selection. C.f. "flattening" https://…

Li: Why don't common variants close to for genes have large effect sizes? Probably natural selection. C.f. "flattening" https://t.co/DVZtffNfM1 #isag2019