Title |
Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10
|
---|---|
Published in |
Frontiers in immunology, September 2018
|
DOI | 10.3389/fimmu.2018.01923 |
Pubmed ID | |
Authors |
Diana Llopiz, Marta Ruiz, Leyre Silva, Pablo Sarobe |
Abstract |
Understanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies. However, these vaccines have demonstrated limited clinical results. Although the low immunogenicity of tumor antigens used and the presence of tumor-associated suppressive factors may in part account for these results, intrinsic vaccine-related factors may also be involved. Vaccines modulate DC functions by inducing activating and inhibitory signals that determine ensuing T cell responses. In this mini review, we focus on IL-10, inhibitory cytokine induced in DC upon vaccination, which defines a suppressive cell subset, discussing its implications as a potential target in combined vaccination immunotherapies. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 13% |
Student > Ph. D. Student | 4 | 13% |
Student > Master | 2 | 7% |
Researcher | 2 | 7% |
Other | 1 | 3% |
Other | 4 | 13% |
Unknown | 13 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Immunology and Microbiology | 4 | 13% |
Medicine and Dentistry | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 3 | 10% |
Unknown | 13 | 43% |