Title |
CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes
|
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Published in |
Frontiers in immunology, September 2018
|
DOI | 10.3389/fimmu.2018.02044 |
Pubmed ID | |
Authors |
Zachary L. Benet, Matangi Marthi, Fang Ke, Rita Wu, Jackson S. Turner, Jahan B. Gabayre, Michael I. Ivanitskiy, Sahil S. Sethi, Irina L. Grigorova |
Abstract |
Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells ex vivo. Two-photon imaging revealed that B cells-intrinsic production of CCL3 promotes their probing by follicular regulatory T cells (Tfr) within GCs of murine lymph nodes. Overall this study suggests that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells in vivo. |
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