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Affinity maturation Centrocytes (° in the LZ) receive positive selection signals from Tfh cells → re-enter the DZ for further rounds of proliferation & SHM → exit the GC as memory °B cells or high-affinity Ab-secreting plasma cells https://t.co/slgA5T
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RT @Leo238umi: ② 📝: Ab somatic hypermutation (SHM) of *GC B cells continued to accumulate throughout the 29-wk priming period w/ evidence o…
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Upon receiving positive selection signals from Tfh cells, centrocytes (B cells in the LZ) re-enter the DZ for further rounds of proliferation & SHM after which they exit the GC as memory B cells or high-affinity Ab-secreting plasma cells. 👉 https://t.c