Title |
Diagnostic Value of microRNA for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
|
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Published in |
Frontiers in Aging Neuroscience, February 2016
|
DOI | 10.3389/fnagi.2016.00013 |
Pubmed ID | |
Authors |
Yong-Bo Hu, Chun-Bo Li, Ning Song, Yang Zou, Sheng-Di Chen, Ru-Jing Ren, Gang Wang |
Abstract |
Sound evidence indicates that microRNAs (miRNAs) are aberrantly expressed in Alzheimer's disease (AD) patients. We performed a systematic review and meta-analysis to investigate the role of miRNA in AD pathogenesis and their clinical diagnostic value; a systematic review of literature and meta-analysis of clinical trials were performed. In the systematic review, 236 papers were included, and we reviewed the dysregulated miRNA expression in different parts of AD patients in order to identify the relationship between aberrantly expressed miRNAs and AD pathology. In the subsequent meta-analysis, seven studies were statistically analyzed with the following results: pooled sensitivity 0.86 (95%CI 0.79-0.90), pooled specificity 0.87 (95%CI 0.72-0.95), diagnostic odds ratio (28.29), and the area under the curve (0.87). In conclusion, our review indicated that aberrant expression of various miRNAs plays an important role in the pathological process of AD, and statistical analysis of quantitative studies reveal the potential value of specific miRNAs in the diagnosis of AD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Estonia | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 132 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 27 | 20% |
Student > Ph. D. Student | 23 | 17% |
Student > Master | 16 | 12% |
Student > Bachelor | 13 | 10% |
Student > Doctoral Student | 7 | 5% |
Other | 23 | 17% |
Unknown | 25 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 25 | 19% |
Agricultural and Biological Sciences | 13 | 10% |
Medicine and Dentistry | 13 | 10% |
Neuroscience | 13 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
Other | 27 | 20% |
Unknown | 35 | 26% |