The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein

https://t.co/GfB7b8ssZE "A number of studies have demonstrated that low intracellular ascorbate concentration exacerbates HIF-1 activation in cancer and normal cells"

https://t.co/GfB7b8ssZE "The hypoxia-inducible factors (HIFs) are heterodimeric pro-survival transcription factors consisting of oxygen-sensitive regulatory α subunits (HIF-1α, HIF-2α, or HIF-3α) and a stably expressed HIF-1β subunit (1, 2)."

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein https://t.co/GfB7b8ssZE

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein: Christina Wohlrab, Margreet C. M. Vissers, Elisabeth Phillips, Helen Morrin, Bridget A. Robinson, Gabi U.… ht