One of the arguments for increasing GWAS sample size is that increase in sample size will result in better polygenic prediction. But here the PRS performance seem to have dropped down compared to the previous 1.3 million GWAS. https://t.co/fwHOPJi8TS
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In which the world’s foremost GWAS whisperer identifies a locus that may be related to an Osler favorite: Ondine’s curse.
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This locus was identified in the two previous GWAS on insomnia. This is not really replication as all the studies used data from the @uk_biobank Having skimmed the papers I see no mention of MYO1H or Ondine's curse in either one. https://t.co/dP5VoRRofk h
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Although there are at least two GWAS on this trait, I haven't been able to find any bona fide confirmed causal genes. https://t.co/kXnIpkcfnz https://t.co/dP5VoRRofk