@SashaGusevPosts The effect of rare variants is known to be significantly large for certain phenotypes
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@pp0196 Yeah, this paper (and a few others recently) is starting to quantify the nulls from WGS. But the Wainschtein et al. h2 analysis was done four years ago [https://t.co/3bjJBlFxfZ] and it's odd there hasn't been a follow-up with the much better data n
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@gabriel_mathy @IronEconomist @rfitz77 Theoretical analyses suggest rare SNPs will close gap with, eg, twin study h2 estimates. But need big samples of *whole genome* (not SNP array) genotypes for working predictors of this type. SE of existing predictor