What was found: Mutant RNA degradation triggers genetic adaptation, resulting in improved genetic fitness. Researchers propose that mRNA decay triggers the transcription of good and healthy genes! (Stainier et al. 2019) https://t.co/upnJOY6z5s https://t.co
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This work builds on landmark papers by @StainierLab, Jun Chen, Jinrong Peng, @MohamedBrolosy, Zhipeng Ma, et al. on nonsense-induced transcriptional compensation https://t.co/507AmBYaqG https://t.co/1YiZQsCgkw 3/
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@slavov_n Also genetic compensation can make nonsense mutations artificially epistatic. Other genes with homologous seq are differentially regulated by Compass/TRAIL. https://t.co/DMN1W6eepa
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@doctorveera Very interesting, reminds me of @MohamedBrolosy paper on genetic robustness, which defines a mechanism for this process: https://t.co/JCV6rrTeDQ;