Title |
Immunomodulatory Effectiveness of Fish Oil and omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells
|
---|---|
Published in |
Journal of Oleo Science, February 2016
|
DOI | 10.5650/jos.ess15256 |
Pubmed ID | |
Authors |
Khurram Rehman, Mohd Cairul Iqbal Mohd Amin, Ng Pei Yuen, Mohd Hanif Zulfakar |
Abstract |
Fish oil is composed of various fatty acids among which omega-3 fatty acids are considered as most beneficial. The effects of fish oil on the activity of a topical anticancer drug, imiquimod, and the immunomodulatory activity of omega-3 fatty acids was investigated in human basal and squamous cell carcinoma cell lines. Imiquimod-fish oil mixture exhibited higher carcinoma cell growth inhibition and immunomodulatory activity than imiquimod alone, especially against squamous cell carcinoma cells. Omega-3 fatty acids exhibited growth inhibition of both basal cell and squamous cell carcinoma cell lines and modulated the immune response. Omega-3 fatty acids of fish oil serve as inducers of interleukin-10, an anti-inflammatory cytokine, and as suppressors of interleukin-6 and tumor necrosis factor-alpha, which not only depress tumor growth but also adequately control the inflammatory side effects of imiquimod. Thus, imiquimod administration with fish oil could be beneficial for inhibition of non-melanoma skin carcinoma cells but further in vivo studies are needed to understand their role in skin cancer. |
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Unknown | 1 | 100% |
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Mendeley readers
Geographical breakdown
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Malaysia | 1 | 4% |
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Demographic breakdown
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Student > Bachelor | 5 | 19% |
Student > Master | 5 | 19% |
Student > Ph. D. Student | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Unspecified | 2 | 8% |
Other | 5 | 19% |
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