Title |
Current Management Strategies in Breast Cancer by Targeting Key Altered Molecular Players
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Published in |
Frontiers in oncology, March 2016
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DOI | 10.3389/fonc.2016.00045 |
Pubmed ID | |
Authors |
Shazia Ali, Neelima Mondal, Hani Choudhry, Mahmood Rasool, Peter N. Pushparaj, Mohammad A. Khan, Maryam Mahfooz, Ghufrana A. Sami, Jummanah Jarullah, Ashraf Ali, Mohammad S. Jamal |
Abstract |
Breast cancer is the second largest disease affecting women worldwide. It remains the most frequently reported and leading cause of death among women in both developed and developing countries. Tamoxifen and raloxifene are commonly used selective estrogen receptor modulators for treatment of breast cancer in women with high risk, although resistance occurs by tamoxifen after 5 years of therapy and both drugs cause uterine cancer and thromboembolic events. Aromatase inhibitors (AIs) are one of the optional modes used for breast cancer treatment. The combination of AIs along with tamoxifen can also be beneficial. Various therapeutic agents from different sources are being studied, which further need to be improved for potential outcome. For this, clinical trials based on large number of patients with optimal dose and lesser side effects have to be more in practice. Despite the clinical trials going on, there is need of better molecular models, which can identify high risk population, new agents with better benefit having less side effects, and improved biomarkers for treating breast cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 14% |
Student > Bachelor | 9 | 14% |
Student > Ph. D. Student | 6 | 10% |
Researcher | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 10 | 16% |
Unknown | 20 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 11% |
Medicine and Dentistry | 7 | 11% |
Agricultural and Biological Sciences | 4 | 6% |
Psychology | 2 | 3% |
Other | 5 | 8% |
Unknown | 24 | 38% |