Title |
Candidate genes of idiopathic pulmonary fibrosis: current evidence and research
|
---|---|
Published in |
The Application of Clinical Genetics, February 2016
|
DOI | 10.2147/tacg.s61999 |
Pubmed ID | |
Authors |
Wei Zhou, Yaping Wang |
Abstract |
Idiopathic pulmonary fibrosis (IPF) is a group of common and lethal forms of idiopathic interstitial pulmonary disease. IPF is characterized by a progressive decline in lung function with a median survival of 2-3 years after diagnosis. Although the pathogenesis of the disease remains unknown, genetic predisposition could play a causal role in IPF. A set of genes have been identified as candidate genes of IPF in the past 20 years. However, the recent technological advances that allow for the analysis of millions of polymorphisms in different subjects have deepened the understanding of the genetic complexity of IPF susceptibility. Genome-wide association studies and whole-genome sequencing continue to reveal the genetic loci associated with IPF risk. In this review, we describe candidate genes on the basis of their functions and aim to gain a better understanding of the genetic basis of IPF. The discovered candidate genes may help to clarify pivotal aspects in the diagnosis, prognosis, and therapies of IPF. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 11% |
United States | 1 | 11% |
Spain | 1 | 11% |
Unknown | 6 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 78% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 19% |
Student > Bachelor | 8 | 13% |
Student > Master | 7 | 11% |
Researcher | 6 | 10% |
Other | 5 | 8% |
Other | 9 | 15% |
Unknown | 15 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 29% |
Biochemistry, Genetics and Molecular Biology | 14 | 23% |
Agricultural and Biological Sciences | 6 | 10% |
Chemistry | 2 | 3% |
Business, Management and Accounting | 1 | 2% |
Other | 4 | 6% |
Unknown | 17 | 27% |