@Madam_Mito Directly related to NAD Biosynthesis, attempting to control Tryptophan to starve the intracellular parasite. The Metabolic Signature of Macrophage Responses https://t.co/dS1KMIrDr4
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訓練されたMΦ→oxLDL等脂質を取り込み、泡沫細胞を形成、解糖二次攻撃でTNFα・IL-6・IL-8・IL-18⬆️ BCG→TI関連cytokine→実験🦠感染を防ぐ https://t.co/XO4u1k5NLf glucose代謝→oxLDL誘導TI https://t.co/X3VF5ga234 解糖代謝⬆️→単球oxLDLへ短期刺激→長期炎症 https://t.co/jyLeQoYKD6 炎症⬆️⬇️MΦ https://t.co/C0h2u3SdhS
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The Metabolic Signature of Macrophage Responses https://t.co/Np6dGbsqDN
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“in macrophages activated in conditions of glucose deprivation; in this manner, the NADPH demand, that cannot rely on PPP, may be met through the NADPH–producing conversion of #citrate into 2-ketoglutarate, catalyzed by the cytosolic NADP+-dependent IDH1.”