High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients

@GeneticLifehack @AmandaB55744931 "help identify patients who might respond well to TLR7 and/or IFN blockade or B cell-targeted therapies." https://t.co/N9BuKDgstu

@GeneticLifehack @AmandaB55744931 TLR7 gain-of-function TLR7 accumulation More: https://t.co/nRWlWKNOY6 https://t.co/7B95Tvor9e https://t.co/nqmw77xpfw https://t.co/EgqSIDDSOT

"TLR7 expression and TLR7 rs3853839 (C/G) genotyping can be useful biomarkers in SLE and other autoimmune diseases to help identify patients who might respond well to TLR7 and/or IFN blockade or B cell-targeted therapies." https://t.co/N9BuKDgstu

"Two other TLR7 SNPs - rs179019 and rs179010 are associated with SLE susceptibility." "Also, changes in miR-3148 can affect TLR7 expression." https://t.co/EgqSIDDSOT