Title |
Milrinone in Enterovirus 71 Brain Stem Encephalitis
|
---|---|
Published in |
Frontiers in Pharmacology, March 2016
|
DOI | 10.3389/fphar.2016.00082 |
Pubmed ID | |
Authors |
Shih-Min Wang |
Abstract |
Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotropic agents, milrinone is selected as a therapeutic agent for EV71- induced PE due to its immunopathogenesis. Milrinone is a type III phosphodiesterase inhibitor that has both inotropic and vasodilator effects. Its clinical efficacy has been shown by modulating inflammation, reducing sympathetic over-activity, and improving survival in patients with EV71-associated PE. Milrinone exhibits immunoregulatory and anti-inflammatory effects in the management of systemic inflammatory responses in severe EV71 infection. |
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Mendeley readers
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Student > Bachelor | 3 | 14% |
Unspecified | 2 | 10% |
Professor | 2 | 10% |
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