@SuzanneESchind1 @WashUNeurology Actually saw a similar trend in vervets with T2D. That both Ab42 and Ab40 dropped in CSF so ratio did not, which we always found puzzling but interesting! https://t.co/mmrMgWUIaU
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Interesting paper on CSF lactate but need to consider conc gradients relative to transporters (e.g. GLUTs, MCTs, etc). Glucose: blood to brain, 5:1 Lactate: brain to blood, 5:1 Ergo, lactate dumps to blood. Our paper in NHPs w/ plasma lactate & CSF
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RT @karchlab: Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys https://t.co/oSK2q5e4LX
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Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys https://t.co/oSK2q5e4LX