Title |
An Overview of B-1 Cells as Antigen-Presenting Cells
|
---|---|
Published in |
Frontiers in immunology, April 2016
|
DOI | 10.3389/fimmu.2016.00138 |
Pubmed ID | |
Authors |
Ana F. Popi, Ieda M. Longo-Maugéri, Mario Mariano |
Abstract |
The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response. |
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