Melanocortin receptors are expressed in multiple tissues and regulate multiple physiological functions. https://t.co/DA0sNUHera https://t.co/CnY8a8HPGT An early-line add-on to MTX would need a clean safety profile (see JAKis). Not sure this is achievable
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The drug’s antiinflammatory effects were assumed to be mediated via MCr3 (similar to AP1189 which is SynAct's main asset; however presumably less subtype-specific). https://t.co/NOiSywFZhD https://t.co/SyAnFW4Thd 4/n
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Referenser: (4/13) https://t.co/99OSMeCpX0 https://t.co/awEd38M8pY (5/13) https://t.co/Ekk3QE0RJv
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New Research: Melanocortin Regulation of Inflammation: Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors… https://t.co/VmnDj1VsvU #Endoc