Title |
Protein Kinase D1 Signaling in Angiogenic Gene Expression and VEGF-Mediated Angiogenesis
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, May 2016
|
DOI | 10.3389/fcell.2016.00037 |
Pubmed ID | |
Authors |
Bin Ren |
Abstract |
Protein kinase D 1 (PKD-1) is a signaling kinase important in fundamental cell functions including migration, proliferation, and differentiation. PKD-1 is also a key regulator of gene expression and angiogenesis that is essential for cardiovascular development and tumor progression. Further understanding molecular aspects of PKD-1 signaling in the regulation of angiogenesis may have translational implications in obesity, cardiovascular disease, and cancer. The author will summarize and provide the insights into molecular mechanisms by which PKD-1 regulates transcriptional expression of angiogenic genes, focusing on the transcriptional regulation of CD36 by PKD-1-FoxO1 signaling axis along with the potential implications of this axis in arterial differentiation and morphogenesis. He will also discuss a new concept of dynamic balance between proangiogenic and antiangiogenic signaling in determining angiogenic switch, and stress how PKD-1 signaling regulates VEGF signaling-mediated angiogenesis. |
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Spain | 1 | 25% |
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Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
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United States | 1 | 3% |
Unknown | 33 | 97% |
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Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 21% |
Student > Bachelor | 5 | 15% |
Researcher | 4 | 12% |
Professor > Associate Professor | 3 | 9% |
Student > Master | 2 | 6% |
Other | 6 | 18% |
Unknown | 7 | 21% |
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Economics, Econometrics and Finance | 1 | 3% |
Other | 3 | 9% |
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