MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas

Overview of attention for article published in Neurologia medico chirurgica, May 2018

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In Diffuse Midline Gliomas - Histone H3 mutation, diffuse DNA are hypomethylated , thus MGMT promoter is unmethylated, it renders DMGs resistant https://t.co/GcnVOqgSGF

06 Oct 2021

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IDH変異型のグリオーマやDiffuse Midline Gliomaにおける MGMTの発現及び治療抵抗性についてのレビュー・IDH変異ではDNAが広範にメチル化される→MGMTプロモーターもメチル化→MGMT発現せず、テモゾロミド奏功・DMGではDNAメチル化がされない→テモゾロミド効果薄い https://t.co/Cy3Puhvbyk

06 Oct 2021

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New in Pubmed: "MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas." https://t.co/Elyq6Jd0BJ

20 Dec 2018

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01 Jun 2018

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