Title |
The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders
|
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Published in |
Frontiers in Psychiatry, January 2012
|
DOI | 10.3389/fpsyt.2012.00039 |
Pubmed ID | |
Authors |
Nikolaos Mellios, Mriganka Sur |
Abstract |
MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence brain plasticity, their relevance for neuropsychiatric diseases with known deficits in synaptic plasticity, such as schizophrenia and autism, has not been adequately explored. In this review we discuss the intersection between current and old knowledge on the role of miRNAs in brain plasticity and function with a focus in the potential involvement of brain expressed miRNAs in the pathophysiology of neuropsychiatric disorders. |
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Geographical breakdown
Country | Count | As % |
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Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 5 | 2% |
Norway | 1 | <1% |
Ireland | 1 | <1% |
United Kingdom | 1 | <1% |
India | 1 | <1% |
Japan | 1 | <1% |
Korea, Republic of | 1 | <1% |
Unknown | 195 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 47 | 23% |
Researcher | 39 | 19% |
Student > Master | 26 | 13% |
Student > Bachelor | 21 | 10% |
Student > Postgraduate | 14 | 7% |
Other | 36 | 17% |
Unknown | 23 | 11% |
Readers by discipline | Count | As % |
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Neuroscience | 37 | 18% |
Biochemistry, Genetics and Molecular Biology | 24 | 12% |
Medicine and Dentistry | 24 | 12% |
Psychology | 10 | 5% |
Other | 14 | 7% |
Unknown | 26 | 13% |