https://t.co/WGVM0BUC7f "Dong et al. has recently shown that inositol-requiring enzyme 1 (IRE1), an ER-nucleus signaling protein, is essential for optimal NK cell anti-tumor and anti-viral responses and works by directly regulating cMyc activity."
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https://t.co/WGVM0BUC7f "Interestingly, neither HIF1α nor glutaminolysis were shown to be important for NK cell metabolism in this study, which is in contrast to other cytotoxic lymphocytes."
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https://t.co/WGVM0BUC7f "These amino acids, glutamine in particular, are imported into the cell via the transporter SLC7A5 where they then turn on cMyc and allow it to regulate NK cell metabolism and function."
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https://t.co/WGVM0BUC7f "Unsurprisingly, inhibition of SREBP also inhibits NK cell functions." "cMyc is another transcription factor that has been shown to be essential for NK cell metabolism ." "In this setting, cMyc is acutely controlled by the availa