https://t.co/PPWmIYjJg6 "Our findings indicate that flunarizine reverses cellular changes caused by SMN deficiency in SMA cells and further support the view of a common pathway in RNA metabolism underlying infantile and adult motor neuron diseases."
3,844 followers
3,844 followers
https://t.co/PPWmIYjJg6 "Notably, TDP-43 is found to co-localize with SMN in nuclear bodies of flunarizine-treated SMA cells."
3,844 followers
https://t.co/PPWmIYjJg6 "We further show that SMN deficiency causes a dissociation of the localization of the SMN complex components from the same nuclear bodies." "The accumulation of TDP-43 in SMN-positive nuclear bodies is also perturbed in SMA cells.
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https://t.co/PPWmIYjJg6 "and markedly reduces the RNA and protein levels of the pro-oxydant thioredoxin-interacting protein (#TXNIP) encoded by an mRNA target of Gemin5."