https://t.co/vC2BKs7sK1 All 3 Lines of PO argument have been debunked. https://t.co/mphDBqL5mS There is no evidence of O-linked glycans in the actual SARS-CoV-2 spike for cells that are relevant to real live hosts or immune systems. https://t.co/QQHFpL0WXl
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
6引7-1 @Daoyu15 All 3 https://t.co/wP3UroyFaq Lines of argument have been debunked. Particularly that there are no evidence of O-linked glycans in the actual SARS-CoV-2 spike https://t.co/tigqhDrVx7 And RmYn02 having 2AA shorter than normal not 3AA longer.
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2 | Glycobiology | Oxford Academic https://t.co/WK6DQBQM27
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
@LThomasRomulus @GadSaad A spike protein is a molecule that a virus uses to enter a cell. https://t.co/omgUz8HJ9t https://t.co/yXmud4AIKl
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
@henri_mourant @tempehlover @edwardcholmes O-linked glycans? https://t.co/pxIIlnCxIm
Mini-🧵 on the predicted O-linked glycans in Proximal Origin: ⤵️
@DavidBahry @jaredpretender @sciencecohen There is a paper confirming the prediction of O-linked glycans while at the same time rejecting the idea that they could create a 'mucin-like domain'. The reason being, how I understand it, that only 3 (potential)
RT @Daoyu15: @pathogenetics https://t.co/px5jnFfBLn Just going to leave this here…… (no clinically significant O-linked Glycosylation found…
RT @Daoyu15: @wanderer_jasnah Highly desirable Heparan sulfate binding motif that is not cleaved. https://t.co/MjkNKVqtQQ PRRAR is not glyc…
RT @Daoyu15: @pathogenetics @Rossana38510044 @ydeigin @stuartjdneil https://t.co/px5jnFfBLn Once put into the presence of an immune system,…
Przy braku glikanów, cząsteczka wirusa nie wniknie do komórki gospodarza. Ta analiza pokazuje, w jaki sposób stan glikozylacji może regulować zakaźność. -- Wzór glikozylacji bS S1 jest kluczowy także dla odp. immuno. np. jeśli )-glikozylacji nie ma ... htt
@BillyBostickson @nailbomb3 @csiv @SharriMarkson "glycosylation can enable the coronavirus to evade both the innate and adaptive immune responses" https://t.co/n4WHOddM2G https://t.co/6kPT70mKFG
RT @Daoyu15: @K_G_Andersen https://t.co/Sj0j89ZeBD O-linked Glycans don’t exist at all in mammalian cell expressed Spike protein. https://…
RT @Daoyu15: @K_G_Andersen https://t.co/Sj0j89ZeBD O-linked Glycans don’t exist at all in mammalian cell expressed Spike protein. https://…
@ChrisMasseyFOIs There’s this article, but spike proteins were isolated from cell-line supernatant, not from infectious individuals: https://t.co/5PaUfbOElZ
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
@PorunChileDigno @camilocammas @CCRadovic2012 De hecho podemos purificar hasta proteínas específicas gracias a conocer el genoma del sars-cov-2, acá mapean las glicosilaciones de la proteína spike y muestran hasta su estructura https://t.co/CoMjjTi5s6
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @flavinkins: @kenpcg @K_G_Andersen @angie_rasmussen @NYMag @nicholsonbaker8 https://t.co/1zmQlYZHlT O-linked glycan claim: debunked. Ful…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @flavinkins: @MrQuantity @SamCoatesSky @Arkancideisreal @MichaelYeadon3 @FatEmperor https://t.co/1zmQlYZHlT Finally, the ORF8 Q27STOP mu…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @flavinkins: @MrQuantity @SamCoatesSky @Arkancideisreal @MichaelYeadon3 @FatEmperor https://t.co/1zmQlYZHlT Finally, the ORF8 Q27STOP mu…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
52 Failed Prediction - Andersen's "O linked Glycans" The function of the predicted O-linked glycans is unclear, but they could create a 'mucin-like domain' that shields epitopes - Kristian G. Andersen. https://t.co/Kvm2Dw3SOm and N- and O-glycosylation htt
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
The S protein RBD located in the S1 subunit of SARS-CoV-2 undergoes a hinge-like dynamic movement to enhance the capture of the receptor RBD with hACE2, displaying 10–20-fold higher affinity for the human ACE2 receptor than SARS-CoV-1 https://t.co/49pd0K8L
The spike protein is a trimeric class I fusion protein and consists of two subunits, namely S1 and S2. The S1 subunit facilitates the attachment of the virus, and subsequently the S2 subunit allows for the fusion of the viral and human cellular membranes h
impossible to ignore introduction of a PRRA insert between S1 & S2: it sticks out like a splinter. This insert creates the furin cleavage sitehttps://bit.ly/3hCJjXG Deducing the N- and O-glycosylation profile of the spike protein SARS-CoV-2 H/T @flavin
RT @flavinkins: Your Glycans were STILL missing! https://t.co/Kd54EwDQpp https://t.co/17TGVO2bai https://t.co/KEcbS2SZNU
RT @flavinkins: https://t.co/wZAaFkAKjO https://t.co/Kd54EwDQpp The S1 subunits they used is legitimate. The QTQTNSPRRARSVASQ sequence is…
RT @flavinkins: @NoWackyScience @still_a_nerd @NNeanderMedical @profvrr @BillyBostickson @Harvard2H https://t.co/Kd54EwDQpp Adding insult t…
RT @flavinkins: @NoWackyScience @still_a_nerd @NNeanderMedical @profvrr @BillyBostickson @Harvard2H https://t.co/Kd54EwDQpp Adding insult t…
RT @flavinkins: @NoWackyScience @still_a_nerd @NNeanderMedical @profvrr @BillyBostickson @Harvard2H https://t.co/Kd54EwDQpp Adding insult t…
RT @flavinkins: @luigi_warren @BillyBostickson @BahulikarRahul @TheSeeker268 @_coltseavers “No obvious signatures” and “immune selection”?…
RT @flavinkins: @luigi_warren @BillyBostickson @BahulikarRahul @TheSeeker268 @_coltseavers “No obvious signatures” and “immune selection”?…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
Thank you for your comments. I was aware of and in love with the papers you cited. 1) We analyzed a recombinant protein from a commercial source which we never claimed it's "Genuine". So far the majority of the S proteins analyzed in papers have been recom
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
RT @LynnFynn3: 3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do n…
3) which is likely the product of an attenyation experiment. Two: the proposed O-linked glycans downstream of the FCS, do not exist. https://t.co/JHirqiPFOv This difference, that between software prediction and experimental result,
RT @flavinkins: @BillyBostickson https://t.co/PU5CHOVu7j So this is clearly engineered--glycoengineered and based on past knowledge--FCS en…
RT @flavinkins: @BillyBostickson https://t.co/PU5CHOVu7j So this is clearly engineered--glycoengineered and based on past knowledge--FCS en…
@Rossana38510044 Issue is that some have detected O-glycosylation for spike (e.g. by mass spec) and not others. See also this publication: https://t.co/3sfLFIGleB