Title |
Dementia with Lewy bodies presenting marked tongue protrusion and bite due to lingual dystonia: A case report
|
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Published in |
Rinshō shinkeigaku Clinical neurology, May 2016
|
DOI | 10.5692/clinicalneurol.cn-000843 |
Pubmed ID | |
Authors |
Yuji Shiga, Yuhei Kanaya, Ryuhei Kono, Shinichi Takeshima, Yutaka Shimoe, Masaru Kuriyama |
Abstract |
We report the patient of a 53-year-old woman who developed subacute-onset marked tonge protrusion and bite. She was diagnosed as dementia with Lewy bodies (DLB) from the clinical features including progressive cognitive decline, visual hallucinations, parkinsonism, and severe insomnia and depression, and the radiological finding of low dopamine transported uptake in basal ganglia by Dat SCAN and low blood circulation in occipital lobe of cerebrum. The patient received 600 mg doses of levodopa for over a year, followed by rotigotine and ropinirole with a rapid increase of dosage. It is believed that these treatments stimulated and sensitized dopamine D1 receptors, thereby inducing lingual dystonia. Furthermore, the patient demonstrated dyspnea and attacks of apnea caused by the closure of bilateral vocal cords due to laryngeal dyskinesia. After initiation of the neuroleptic, olanzapine, for a short duration, the high dose of levodopa overlapped with neuroleptic sensitivity, suggesting DOPA-induced dystonia and dyskinesia. This interaction can sometimes lead to lethal adverse events, and must be considered very important when treating patients with DLB. |
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