Title |
Pharmacologic management of bone-related complications and bone metastases in postmenopausal women with hormone receptor-positive breast cancer
|
---|---|
Published in |
Breast cancer targets and therapy, May 2016
|
DOI | 10.2147/bctt.s97963 |
Pubmed ID | |
Authors |
Matthew Grzywacz, Denise Yardley |
Abstract |
There is a high risk for bone loss and skeletal-related events, including bone metastases, in postmenopausal women with hormone receptor-positive breast cancer. Both the disease itself and its therapeutic treatments can negatively impact bone, resulting in decreases in bone mineral density and increases in bone loss. These negative effects on the bone can significantly impact morbidity and mortality. Effective management and minimization of bone-related complications in postmenopausal women with hormone receptor-positive breast cancer remain essential. This review discusses the current understanding of molecular and biological mechanisms involved in bone turnover and metastases, increased risk for bone-related complications from breast cancer and breast cancer therapy, and current and emerging treatment strategies for managing bone metastases and bone turnover in postmenopausal women with hormone receptor-positive breast cancer. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 21% |
Student > Master | 5 | 18% |
Researcher | 3 | 11% |
Student > Postgraduate | 3 | 11% |
Professor | 2 | 7% |
Other | 7 | 25% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 18 | 64% |
Agricultural and Biological Sciences | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Unspecified | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Other | 0 | 0% |
Unknown | 4 | 14% |