Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19

https://t.co/mhLqhmrtps Kynurenine "Kyn is also a potent vasodilator of systemic arteries ... In chronic models of pulmonary arterial hypertension, Kyn exerted acute pulmonary vasodilatation in synergy with nitric oxide"

https://t.co/mhLqhmrtps "a feed-forward loop constraining hyperinflammation is established, whereby IDO1 generates Kyn, an activating ligand for AhR that, in turn, will enhance IDO1 expression in DCs (Manni et al., 2020)."

Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in #COVID19 https://t.co/mhLqhmrtps "A tight correlation has been demonstrated between IL-6–driven inflammation and the defective activity of IDO1"

RT @FrontPharmacol: New Research: Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19 https://t.co/eJ9td…

New Research: Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19 https://t.co/eJ9tdEPFIG #pharmacology

トリプトファン代謝がCOVID-19のトシリズマブの有効性に及ぼす影響 COVID-19関連サイトカイン放出症候群では、IDO1によって生成される免疫調節機能を持つトリプトファン由来の代謝物が欠乏しており、その欠乏はCOVID-19の炎症性イベントを悪化させる可能性がある。 https://t.co/AXq4BBswjH

Covid 19 ağır seyreden hastalarda meydana gelen sitokin fırtınasına bağlı komplikasyonları hafifletmede Tocilizumab ın etkinliği. Hedef Il-6 yanıt kontrolü https://t.co/52Fec5ehs7