Title |
Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, June 2016
|
DOI | 10.3389/fncel.2016.00144 |
Pubmed ID | |
Authors |
Yuta Takahashi, Zhiqian Yu, Mai Sakai, Hiroaki Tomita |
Abstract |
A wide variety of studies have identified microglial activation in psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but robust, studies have detected activation of peripheral monocytic cells in psychiatric disorders. Considering the origin of microglia, as well as neuropsychoimmune interactions in the context of the pathophysiology of psychiatric disorders, it is reasonable to speculate that microglia interact with peripheral monocytic cells in relevance with the pathogenesis of psychiatric disorders; however, these interactions have drawn little attention. In this review, we summarize findings relevant to activation of microglia and monocytic cells in psychiatric disorders, discuss the potential association between these cell types and disease pathogenesis, and propose perspectives for future research on these processes. |
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Country | Count | As % |
---|---|---|
Australia | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 102 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 17% |
Student > Master | 16 | 16% |
Researcher | 15 | 15% |
Student > Bachelor | 7 | 7% |
Other | 7 | 7% |
Other | 17 | 17% |
Unknown | 23 | 22% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 22 | 21% |
Medicine and Dentistry | 21 | 20% |
Neuroscience | 12 | 12% |
Biochemistry, Genetics and Molecular Biology | 8 | 8% |
Psychology | 6 | 6% |
Other | 8 | 8% |
Unknown | 26 | 25% |