Title |
Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events
|
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Published in |
Frontiers in Aging Neuroscience, June 2016
|
DOI | 10.3389/fnagi.2016.00132 |
Pubmed ID | |
Authors |
Vitalii V. Cozac, Michael M. Ehrensperger, Ute Gschwandtner, Florian Hatz, Antonia Meyer, Andreas U. Monsch, Michael Schuepbach, Ethan Taub, Peter Fuhr |
Abstract |
To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD). We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups. A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01). The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects. |
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