https://t.co/ieHJ4uVa0K "Transformation of Ang II to III and III to IV by aminopeptidases A and N, respectively, activates AT4R, which is also known as insulin-regulated aminopeptidase."
https://t.co/ieHJ4uVa0K "Ang II also binds the type 2 receptor (AT2R), which exerts inhibitory actions on AT1R cell signals by promoting vasodilation and natriuresis."
https://t.co/ieHJ4uVa0K "has a biphasic effect on sodium reabsorption in the gut (promotes at low concentrations, inhibits at high concentrations) and increases blood pressure, which is associated with increased neuronal and immune cell production of the
https://t.co/ieHJ4uVa0K "The binding of Ang II to AT1R promotes vasoconstriction; induces the production of aldosterone, which promotes renal tubular sodium reabsorption;"
https://t.co/ieHJ4uVa0K "Liver-produced angiotensinogen is cleaved by renin into Ang I, which is further cleaved by a ubiquitous membrane and soluble ectoprotein, ACE, into Ang II."
https://t.co/ieHJ4uVa0K "Pro-renin is transformed into active renin by proteases, including kallikrein." "Renin may also be released from mast cells activated by oxidative injury."
https://t.co/ieHJ4uVa0K "The use of a highly selective NK1 antagonist (aprepitant), which blocks SP binding to NK1 on adrenal zona glomerulosa cells, may also be beneficial in reducing aldosterone levels that in turn, promote IL-6 production."
https://t.co/ieHJ4uVa0K "Possibly, ACE2 dampens Ang II-induced production of interleukin (IL)-6 (via aldosterone) and reduces the downstream formation of Th17 cells."
https://t.co/ieHJ4uVa0K "While the effects of ACEi/ARBs and soluble ACE2 in #COVID19 are not fully known, ACE2 is an endogenous inhibitor of the ACE/Ang II/AT1R pathway and the downstream vasoconstrictive, inflammatory, prothrombotic, and fibrotic respons
#COVID19 Usurps Host Regulatory Networks https://t.co/ieHJ4uVa0K
Źródła literaturowe dla zainteresowanych...
The NIH just put out the kitchen sink of a paper and has helped to weave together the systems Covid-19 affects in the host. Pretty Wow. Covers Mast Cells, MRGPRX2 GPRC receptor, Platelet activation, Bradykinin and more. #COVIDー19 #LongCovid #COVID https:/
RT @IdiUcv: La COVID-19 usurpa las redes reguladoras del huésped. https://t.co/QzREX1Tx9a https://t.co/IPKbKf0BZ8
RT @IdiUcv: La COVID-19 usurpa las redes reguladoras del huésped. https://t.co/QzREX1Tx9a https://t.co/IPKbKf0BZ8
RT @IdiUcv: La COVID-19 usurpa las redes reguladoras del huésped. https://t.co/QzREX1Tx9a https://t.co/IPKbKf0BZ8
RT @IdiUcv: La COVID-19 usurpa las redes reguladoras del huésped. https://t.co/QzREX1Tx9a https://t.co/IPKbKf0BZ8
RT @IdiUcv: La COVID-19 usurpa las redes reguladoras del huésped. https://t.co/QzREX1Tx9a https://t.co/IPKbKf0BZ8
RT @IdiUcv: La COVID-19 usurpa las redes reguladoras del huésped. https://t.co/QzREX1Tx9a https://t.co/IPKbKf0BZ8
La COVID-19 usurpa las redes reguladoras del huésped. https://t.co/QzREX1Tx9a https://t.co/IPKbKf0BZ8
RT @SophieSRapp: If you want to get deep into how COVID-19 works inside the body.
RT @SophieSRapp: If you want to get deep into how COVID-19 works inside the body. https://t.co/jQ0qmIjR7U
RT @SophieSRapp: If you want to get deep into how COVID-19 works inside the body. https://t.co/jQ0qmIjR7U
Basically, this exhaustive review confirms almost every theory re: CoV-2 that #JosefPenninger has been talking about. Little wonder, given his long involvement with ACE2.
RT @SophieSRapp: If you want to get deep into how COVID-19 works inside the body. https://t.co/jQ0qmIjR7U
If you want to get deep into how COVID-19 works inside the body.
August 14, 2020: "COVID-19 Usurps Host Regulatory Networks" by Colleen S. Curran, Donna R. Rivera and Jeffrey B. Kopp, National Institutes of Health: https://t.co/138rpwbALs #Review