Title |
T-bet and Eomesodermin in NK Cell Development, Maturation, and Function
|
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Published in |
Frontiers in immunology, June 2016
|
DOI | 10.3389/fimmu.2016.00241 |
Pubmed ID | |
Authors |
Federico Simonetta, Amandine Pradier, Eddy Roosnek |
Abstract |
Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Austria | 1 | <1% |
Unknown | 156 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 44 | 28% |
Student > Master | 22 | 14% |
Researcher | 19 | 12% |
Student > Bachelor | 14 | 9% |
Student > Doctoral Student | 10 | 6% |
Other | 14 | 9% |
Unknown | 34 | 22% |
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Agricultural and Biological Sciences | 25 | 16% |
Biochemistry, Genetics and Molecular Biology | 24 | 15% |
Medicine and Dentistry | 15 | 10% |
Computer Science | 2 | 1% |
Other | 8 | 5% |
Unknown | 38 | 24% |